Accession Number:

AD0766977

Title:

Experimental Human Exposure to Propylene Glycol Dinitrate

Descriptive Note:

Final rept.

Corporate Author:

MEDICAL COLL OF WISCONSIN MILWAUKEE DEPT OF ENVIRONMENTAL MEDICINE

Report Date:

1973-09-01

Pagination or Media Count:

50.0

Abstract:

Human volunteers were exposed to PGDN vapor at concentrations of 0. 03, 0.1, 0.2, 0.35, 0.5, and 1.5 ppm. Exposure to concentrations of 0.2 and greater produced disruption of the organization of the visual evoked response VER and headache in the majority of subjects. Subjects repeatedly exposed to 0.2 ppm for 8 hours on a daily basis developed a tolerance to headache induction, but the alteration in VER morphology appeared cumulative. Marked impairment in balance became manifest after exposure to 0.5 ppm for 6 12 hours while 40 minutes of exposure to 1.5 ppm added eye irritation to the list of symptoms.

Subject Categories:

  • Toxicology
  • Environmental Health and Safety

Distribution Statement:

APPROVED FOR PUBLIC RELEASE