Experimental Human Exposure to Propylene Glycol Dinitrate
MEDICAL COLL OF WISCONSIN MILWAUKEE DEPT OF ENVIRONMENTAL MEDICINE
Pagination or Media Count:
Human volunteers were exposed to PGDN vapor at concentrations of 0. 03, 0.1, 0.2, 0.35, 0.5, and 1.5 ppm. Exposure to concentrations of 0.2 and greater produced disruption of the organization of the visual evoked response VER and headache in the majority of subjects. Subjects repeatedly exposed to 0.2 ppm for 8 hours on a daily basis developed a tolerance to headache induction, but the alteration in VER morphology appeared cumulative. Marked impairment in balance became manifest after exposure to 0.5 ppm for 6 12 hours while 40 minutes of exposure to 1.5 ppm added eye irritation to the list of symptoms.
- Environmental Health and Safety