A Study of Differences in the Response of Germ-Free and Conventional Rats to Various Centrally Acting Drugs.
Progress rept. no. 1 (Final), 1 Jul 71-30 Jun 73,
HOWARD UNIV WASHINGTON D C COLL OF MEDICINE
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The effects of certain central nervous system stimulants and depressants were investigated in the germ-free and conventional Sprague-Dawley rats. Less number of germ-free rats showed convulsions and lethal toxicity at 1, 1.5 and 2 mgkg doses of strychnine and 40, 60 and 80 mgkg doses of pentylenetetrazol. They also appeared to sleep longer than the conventional rats under 40 mgkg of pentobarbital. These results thus indicate a trend in the difference in the susceptibility of the germ-free and conventional rats to these neurotropic drugs. Author