Use of Red Cell Survival to Demonstrate a Transient Transfusion-Induced Antibody in Canine Subjects.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Initial findings in transfused dogs showed a red cell survival pattern of apparently normal decline of radioactivity that abruptly shifted to a rapid loss 4-5 days after transfusion in three of 15 subjects. These animals were compatible on pretransfusion screening. Rising antibody titers were detected in the week following transfusion which persisted for 15 weeks and then disappeared. After the titer was negative, the animals became compatible again so the three subjects and a compatible control were retransfused using the same donors as previously. An additional set of two pairs consisting of one negative and one incompatible recipient was transfused. Red cell survival in the three test subjects showed a similar pattern of slow loss until the fourth day and then a rapid decline. At the same time, the antibody titer began to rise and remained high for at least 6 more weeks. In the animals already incompatible on pretransfusion testing, decline in red cell activity was rapid from the start however, in one, the tagged cells were totally removed by 3 days while the other showed a slower loss. Antibody levels were constantly present and at high levels. Patterns of red cell loss and changing antibody titer indicated active red cell destruction and the red cell survival pattern appeared to illustrate differences in immunological response. Author
- Anatomy and Physiology
- Medicine and Medical Research