The Effects of Washing, EDTA, Magnesium and Calcium on Oxidative Phosphorylation and Respiratory Rates of Mitochondria from Heat- and Cold-Acclimated Rats.
DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
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The ADPO ratios of single-sedimented liver mitochondria from heat-acclimated Sprague-Dawley rats were greater than control and cold-acclimated ratios heatcontrolcold. These differences were abolished by washing the mitochondria. EDTA in the homogenate reduced to a greater extent the magnesium and calcium content in mitochondria of cold- than heat-acclimated preparations. Elevation of magnesium in the medium increased ADPO values and reduced respiratory rates in all mitochondrial populations. During calcium respiration ADPO ratios were decreased significantly in cold-acclimated mitochondria. Author
- Stress Physiology