Hemoglobin Function in Stored Blood: XIII. A Citrate-Adenine Preservative with Optimal pH to Maintain Red Cell 2,3-DPG (Function) and ATP (Viability).
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Increasing the pH by a 0.5 increment over the commonly used preservative, acid-citrate-dextrose ACD, results in a significant improvement in 2,3-DPG, with no significant loss in concentrations of ATP. The intermediate pH preservative, 6.0, also had 2,3-DPG concentrations which equalled those of the low pH preservatives from the 21st to 42nd day. A citrate-adenine preservative, with a pH between 5.5 and 6.0, would seem to be optimal for maintenance of hemoglobin function and red cell viability. Author
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