Induction of Axon Growth and Increased Acetylcholinesterase Production in Mouse Neuroblastoma by Sulfur Mustards.
Technical rept. May 17-Nov 72,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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The bifunctional alkylating agent, di-2-chloroethyl sulfide HS, induced acetylcholinesterase AChE synthesis and axon formation in mouse neuroblastoma cells in vitro. The monofunctional analog, 2-chloroethylethyl sulfide CEES, produced similar effects, but much higher concentrations were required. The induction by HS occurred even when the induction of axon formation was blocked by vinblastine. The enzyme induction by HS was inversely related to the ability of the monolayer cells to divide, as measured by observing the appearance of microcolonies or the disappearance of single cells. Author
- Anatomy and Physiology