Uptake of a Metabolically Inert Amino Acid by Brain Tissue During High Pressure Oxygen Exposure,
DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
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Large intraperitoneal doses of gamma-aminobutyric acid GABA protect animals against high pressure oxygen HPO-induced convulsions, apparently by elevation of brain GABA levels. Although normally impermeable to GABA, the blood-brain barrier may be affected by HPO to facilitate GABA transfer into the brain. Attempts to demonstrate such an HPO-accelerated neuronal accumulation of GABA have been unsuccessful, possibly due to metabolism of accumulating GABA by brain GABA-transaminase. Use of an inert amino acid, such as alpha-amino-isobutyric acid AIB, to assess blood-brain barrier function under HPO would circumvent the problem of intraneuronal metabolism of the administered amino acid. The effect of HPO on the uptake of AIB into the brain from the blood is reported in this study.
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