Cell Wall Degrading Enzymes: An Approach to the Control of Fungal Infection of Human Burns.
RUTGERS - THE STATE UNIV NEW BRUNSWICK N J DEPT OF BIOCHEMISTRY AND MICROBIOLOGY
Pagination or Media Count:
The increased occurence of invasive fungal infections in burn wounds is probably a direct result of the more effective bacterial control measures recently introduced. Systemic and topical chemotherapy have failed to control zygomycetes in burns, and frequently these infections lead to major amputation or death. Since zygomycetes have biochemically distinctive cell walls, potential methods for their selective control are possible including the application of cell wall degrading enzymes or inhibitors of cell wall synthesis. The results presented cover the former approach the isolation and application of cell wall degrading enzymes towards the control of fungal Zygomycete infection of burn wounds. The possibility of testing inhibitors of fungal growth is also discussed.