Resistance to Viral Challenge in the Days Immediately Following Vaccination.
Annual progress rept. Apr 72-31 Mar 73,
YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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Mice vaccinated with a single injection of formalin-inactivated suspensions of mouse brain tissue infected with arboviruses were protected against a challenge injection administered hours later. The protection observed during the first 2 days after vaccination was nonspecific, in that it appeared not only with the homologous virus but also with antigenically unrelated viruses this phase may be associated with an interferon-like activity of the serum. Overlapping the nonspecific phase was one of specific protection which appeared well established by the 3rd or 4th day after vaccination. Serum neutralizing antibodies against the homologous viruses were detected as early as 24 hours after vaccination, nearly always by day 3. The effect of cytoxan on the early phase of protection was not predictable in some instances cytoxan hardly depressed resistance, in others it lowered or annulled it. Modified author abstract
- Medicine and Medical Research