Accession Number:

AD0763621

Title:

The Lipid Core Model of Lipoproteins,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGICAL SCIENCES

Report Date:

1973-01-27

Pagination or Media Count:

26.0

Abstract:

Several aspects of the lipid core model for lipoproteins were examined in a quantitative manner. Detailed consideration was given to a geometric factor relevant to the packing of lipids on curved surfaces, which allowed computation of the maximum amount of lipid which can be accommodated about a sphere of given size. The model was found to be consistent with presently available data for size and shape of very low density lipoproteins of serum and egg yolk low density lipoproteins. In addition, the model led to hypotheses regarding the organization and spatial arrangement of lipids within the core, the factors controlling these arrangements, and the way the lipids may interact with protein and water. The results were consistent also with dynamic equilibria where triglyceride moves from a neutral lipid nucleus to a phospholipid-cholesterol interfacial region, with concomitant changes in the structural arrangement of the interfacial lipids. Also consistent was the possibility of structural transitions or differences in packing behavior of interfacial lipids at fixed interfacial triglyceride concentrations. Modified author abstract

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE