Accession Number:

AD0763355

Title:

The Measurement of Pulmonary Extravascular Water Volume during Exposure to Simulated High Altitude,

Descriptive Note:

Corporate Author:

NAVAL AEROSPACE MEDICAL RESEARCH LAB PENSACOLA FL

Personal Author(s):

Report Date:

1973-01-03

Pagination or Media Count:

17.0

Abstract:

To investigate basic mechanisms operative in high altitude pulmonary edema, pulmonary extravascular water volume Qpevw was measured in 11 unanesthetized calves exposed to atmospheres equivalent to 12,000 and 16,000 feet. Measurements were made by a double indicator dilution technique at sea level and after continuous exposure of 24, 48, and 72 hours. Thirty-five duplicate measurements from 15 experiments yielded a test-retest reliability coefficient of 0.84. Data from 15 experiments were technically satisfactory after exposure of 24 hours 13 experiments after 48 hours exposure and 7 experiments after 72 hours exposure. After 24 hours exposure the mean increase in Qpevw was 42.7 ml p.025 after 48 hours 79.3 ml p.005 and after 72 hours, 29.3 ml N.S.. There was no significant difference in Qpevw for the same duration of exposure at 12,000 feet and 16,000 feet. It is concluded that Qpevw increases in the bovine lung after exposure to high altitude. Author

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE