Histoincompatibility Reactions in Bone Marrow Transplantation and their Control.
NORTH CAROLINA UNIV CHAPEL HILL DENTAL RESEARCH CENTER
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The scope and efficacy of bone marrow therapy in the treatment of aplastic and genetically determined anemias, leukemias, and certain congenital and acquired immunologic deficiency states would be greatly enhanced if a method could be found that would eliminate from marrow preparations those mature lymphocytes that produce graft-versus-host GVH disease without adversely affecting the erythroid, myeloid and lymphoid stem cells. Previous observations have suggested that properly raided and absorbed antisera to whole serum polyvalent anti-immunoglobulin, gamma-globulin, K and lambda lightchains, or to the theta antigen in the mouse, together with complement, are selective in their cytotoxic action against those cells involved in cell-mediated and antibody-dependent immune responses. Thus the use of these specific antisera against cell-associated immunoglobulin components or lymphocyte-specific antigens offer a possible method for the prevention of marrow induced GVH disease. In the experiments reported, antisera against the theta antigen and against whole mouse serum were used in an attempt to modify or abrogate a severe form of GVH disease produced by the transfusion of bone marrow and spleen cells into lethally irradiated allogeneic mice.
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