Penetration, Fate and Biological Effects of Exogenous DNA into the Cells of Irradiated Mammalian Tissues.
Final technical rept.,
CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE MOL (BELGIUM)
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Labelled bacterial DNA infused in rat cartoid becomes integrated in the genome of different target organs as double stranded material, covalently bound to the non replicating strands of the recipient DNA. Part of the foreign DNA replicates in the recipient cells. Both processes are suppressed by lethal X-irradiation. Post irradiation DNA treatment greatly improves the organ resistance to X-rays, apparently through side effects. DNA appears to bind to specific membrane receptors and to penetrate into living cells by a process differing from pinocytosis. Author