Accession Number:

AD0762202

Title:

Penetration, Fate and Biological Effects of Exogenous DNA into the Cells of Irradiated Mammalian Tissues.

Descriptive Note:

Final technical rept.,

Corporate Author:

CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE MOL (BELGIUM)

Report Date:

1972-09-01

Pagination or Media Count:

53.0

Abstract:

Labelled bacterial DNA infused in rat cartoid becomes integrated in the genome of different target organs as double stranded material, covalently bound to the non replicating strands of the recipient DNA. Part of the foreign DNA replicates in the recipient cells. Both processes are suppressed by lethal X-irradiation. Post irradiation DNA treatment greatly improves the organ resistance to X-rays, apparently through side effects. DNA appears to bind to specific membrane receptors and to penetrate into living cells by a process differing from pinocytosis. Author

Subject Categories:

  • Biochemistry
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE