Ultrastructural Cognates of Mammalian Freeze-Thaw Survival Curves in vitro.
Final technical rept. 1 May 69-30 Apr 72,
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The author has defined patterns of cellular injury and repair following exposure of the L5178y Murine Lymphoblasts to 4C. Anatomic studies uncovered severe injury at variance with minimal damage defined by growth andor survival curves. Additional studies included monolayer cultures of normal and galactosemic human fibroblasts and differentiated gastric mucosal cells. Studies on mitochondrial enzyme localization and damaged mitochondrial functional reconstitution are also reported. Author