Effects of Albumin and Urea on Hydrostatic Edema in the Perfused Lung.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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Hydrostatic interstitial pulmonary edema was induced in isolated perfused canine lungs to evaluate the effects of treatment with osmotic agents. In 14 preparations after induced venous hypertension adding fluid weights of 20 gms, 30 gms, 40 gms, or 60 gms representing 33 to 100 of normal lobe weight, venous pressure was returned to levels of zero or below without additional treatment. Albumin 25 gms was added to 23 preparations and urea 10 gms added to 10 lungs prepared in a similar fashion. Albumin improved venous PO2 only after the minimal load but there was no significant effect on pulmonary compliance. No improvement in either parameter occurred after urea treatment. Significantly lower weights after albumin or urea treatment were noted after varied fluid loads but were not accompanied by proportional improvement in lung function. In the isolated lung preparation with no outlet for fluid excretion, the therapeutic effectiveness of osmotic agents alone is obviously limited, but the deleterious effects of hydrostatic interstitial edema are not readily reversed by addition of osmotic agents to the perfusate. Author Modified Abstract
- Medicine and Medical Research