Accession Number:

AD0759718

Title:

Effects of Indomethacin on the Pulmonary Vascular and Airway Resistance Responses to Pulmonary Microembolization.

Descriptive Note:

Technical rept.,

Corporate Author:

OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY

Personal Author(s):

• Nakano,Jiro
• McCloy,Robert B. , Jr

Report Date:

1973-02-15

Pagination or Media Count:

13.0

Abstract:

The effects of indomethacin on the circulatory and respiratory responses to BaSO4-induced pulmonary microembolization were studied in anesthetized dogs. It was found that indomethacin blocks the bronchoconstrictor response but not the circulatory responses to pulmonary embolization. It is suggested that indomethacin blocks the formation and release of prostaglandins due to pulmonary embolization. Author

Descriptors:

• (*RESPIRATORY SYSTEM
• DRUGS)
• (*EMBOLISM
• *LUNG)
• BLOOD CIRCULATION
• OBSTRUCTION(PHYSIOLOGY)
• PHARMACOLOGY

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE