Histoincompatibility Reactions in Bone Marrow Transplantation and Their Control.
NORTH CAROLINA UNIV CHAPEL HILL
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The research proposed has the following objectives Prepare or to purchase specific antisera against mouse lymphoid cell-associated immunoglobulin components or lymphocyte-specific antigens e.g., gamma-globulin, kappa and lambda light chains or to the 0 antigen Selectively absorb these antisera so that they retain their specific activity but manifest no deleterious effect on erythroid or myeloid stem cells Use such antisera in the treatment of donor mice or donor bone marrow cells in an effort to eliminate mature lymphoid cells and so give 100 one hundred day survival in a graft-versus-host system that would otherwise be 100 lethal. The report details the present status of the work.
- Medicine and Medical Research