Effect of Superimposed Metabolic Alkalosis on the Chronic Acclimatization to a CO2-Rich Atmosphere.
ALBERT EINSTEIN COLL OF MEDICINE BRONX N Y
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Cats breathed various concentrations of CO2 while being fed on either a normal diet, dietetic tuna fish plus bicarbonate or dietetic tuna fish plus THAM buffer over a period of 5 to 14 days. Total CO2 content and pCO2 of arterial blood and cerebrospinal fluid CSF were monitored periodically. Results suggest that the respiratory adjustment to chronic CO2 exposure evaluated by the PaCO2-PICO2 relationship is more closely related to the change in bicarbonate and hydrogen ion concetrations of CSF and is little influenced by the change in arterial bicarbonate and hydrogen ion concetrations. The results also suggest that there is an effective, but limited regulatory mechanism that controls the transport of bicarbonate ion across the blood-brain barrier which prevents excessive build-up of cerebrospinal fluid bicarbonate during chronic exposure to elevated CO2 levels. Author
- Stress Physiology