Accession Number:

AD0759341

Title:

Lateral Ventricular Pressure Changes in the Monkey Induced by Supralethal Doses of Mixed Gamma-Neutron Radiation,

Descriptive Note:

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• Turbyfill,C. L.
• Flinton,J. H.
• Roudon,R. M.
• Kieffer,V. A.

Report Date:

1972-12-01

Pagination or Media Count:

15.0

Abstract:

Monkeys were surgically implanted with catheters to monitor lateral ventricular pressure of the brain, aortic and venous pressures, carotid flow, and respiratory and heart rates and were irradiated with a pulse of 4000 rads of mixed gamma-neutron whole-body radiation. Immediately following irradiation the lateral ventricular pressure increased to approximately 1.4 times the preirradiation level. The lateral ventricular pressure returned to preirradiation levels by 6 minutes postirradiation. The aortic pressure decreased following irradiation and did not return to preirradiation levels during the 1-hour postirradiation monitoring period. The respiratory and heart rates were increased following irradiation. The increase observed in the lateral ventricular pressure of the monkey, following irradiation, does not appear to approach levels that would effectively limit cerebral capillary perfusion and induce or sustain behavioral incapacitation, providing normal autoregulatory vasoactive mechanisms are maintained. Author

Descriptors:

• (*RADIATION EFFECTS
• *CEREBROVASCULAR SYSTEM)
• BRAIN
• BLOOD PRESSURE
• BLOOD CIRCULATION
• RESPIRATION
• HEART
• PHYSIOLOGY
• SUBLETHAL DOSAGE
• PRIMATES
• MONKEYS

Subject Categories:

• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE