Drug Therapy of Acute Pulmonary Insufficiency.
Annual summary rept. 1 Apr 72-1 Jan 73,
PENNSYLVANIA UNIV PHILADELPHIA DEPT OF PHARMACOLOGY
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Two compounds for treatment of pulmonary insufficiency were selected for further investigation. Eriodictyol administered orally to rhesus monkeys prevented or reduced the pulmonary congestion and edema induced by iodoacetamide. Other compounds known to provoke pulmonary edema in the dog alloxan and ANTU did not induce similar effect in the monkey. The naphthoquinone compound previously demonstrated to protect rodents from pulmonary edema was less effective in monkeys. In the dog heart, eriodictyol is non-toxic and potentiates the coronary vasodilator action of adenosine, a substance known to be released by hemolysis. Two water-soluble benzoylcarbinols were tested in mice. Both were effective in preventing carbon dioxide-induced pulmonary edema. However, benzoylcarbinoltrimetyl acetate produced pulmonary hemorrhages. Benzoylcarbonolmorpholine acetate was selected for future studies to determine if intravenous injection would be effective in treating or reversing acute pulmonary insufficiency. Author Modified Abstract