Accession Number:

AD0758957

Title:

Effect of Hydrochlorothiazide on +Gz Tolerance in Normotensives.

Descriptive Note:

Research paper,

Corporate Author:

DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s):

Report Date:

1972-01-01

Pagination or Media Count:

5.0

Abstract:

Following an episode of incapacitating tetany in a pilot on diuretic therapy for hypertension, an investigation was made on the effect of Hydro-diuril on tolerance to flight stresses. Six healthy, normotensive males were given a familiarization G-tolerance test to grey-out GTTG on the human accelerator, followed by a control GTTG and a four-minute exposure to 2.5 Gz during which heart rate, blood pressure, and forearm blood flow were recorded BP and Q at 2.5 Gz. They were then given 50 mg of Hydro-diuril twice daily, and the GTTG, BP, and Q at 2.5 Gz were repeated after 2 and 4 weeks on the drug. It is concluded that tolerance to Gz acceleration is reduced by Hydro-diuril in normotensive adult male subjects. Since this drug is used to treat some active aircrew, it is urgent that its effect on G-tolerance be determined in hypertensives. Author Modified Abstract

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE