Accession Number:
AD0758921
Title:
Correlation of Animal, Crypt and Stem Cell Survival in Fission Neutron Irradiated Mice. A Chemical Protection Study.
Descriptive Note:
Annual rept. Oct 71-Oct 72,
Corporate Author:
LOUISVILLE UNIV KY SCHOOL OF MEDICINE
Personal Author(s):
Report Date:
1972-11-01
Pagination or Media Count:
77.0
Abstract:
Newly synthesized anti-radiation drugs WR-2721, WR-638, WR-1607, WR-2347, WR-3689, WR-77913 and WR-109342 were compared to MEA for their ability to protect against 4 MeV x-rays and fission neutrons. Intestinal crypt survival, lethality, total and per crypt cellularity were the parameters tested. The relative potency of the drugs to protect against X-irradiation in descending order is WR-2721, WR-638, WR-77913, WR-2347, MEA, WR-1607 and WR-3689. The evaluation of WR-109342 is incomplete. The relative potency of these drugs to protect against fission neutron irradiation in descending order is WR-2721, WR-107342, WR-638, MEA, and WR-2347. WR-1607 produced no protective effect, and WR-3689 and WR-77913 are incomplete. Author
Descriptors:
Subject Categories:
- Radiobiology
- Pharmacology