Accession Number:

AD0758660

Title:

Sequential Search of Optimal Dosages: The Linear Regression Case.

Descriptive Note:

Technical rept.,

Corporate Author:

CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF MATHEMATICS AND STATISTICS

Personal Author(s):

Report Date:

1973-04-15

Pagination or Media Count:

32.0

Abstract:

The present paper summarizes all the previous results of the authors in the area of sequential search of optimal dosages, under linear regression of dosage-toxicity. The optimal dosage is defined as the largest dosage for which the probability that the patients toxicity does not exceed a given threshold is at least gamma, 0 gamma 1. The search problem is a valid design problem when some or all of the regression parameters are unknown. In the present paper we provide a general introductory discussion concerning the applicability of the derives procedures, set up the general criteria and present the various sequential methods of on-line experimentation, which search for the location of the optimal dosage. Author

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE