Mechanisms of Hemolysis.
Annual summary rept.,
CALIFORNIA UNIV SAN DIEGO LA JOLLA SCHOOL OF MEDICINE
Pagination or Media Count:
Erythrocyte damage by surface or wall interaction is accompanied by the release of free 2,3 DPG to the plasma, in greater concentrations than normally exist within the cell, compared to hemoglobin. Similar findings occur after lysis due to shear stress and osmotic forces. Following incubation, 2,3 DPG is rapidly depleted in both control and damaged specimens, and the oxyhemoglobin dissociation curve is shifted to the left to the expected degree. Only after osmotic lysis is RBC ATP concentration substantially depleted, although free plasma ATP is demonstrable following both shear and osmotically induced inuury. Author
- Anatomy and Physiology