Endocrine and Pulmonary Response to Hemorrhagic Shock.
Annual progress rept. 30 Jun 72-30 Jun 73,
BOSTON UNIV MASS SCHOOL OF MEDICINE
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Insulin secretion after an exogenous glucose challenge was measured in primates subjected to hemorrhage with intact adrenal glands and in animals after adrenalectomy some of which received hydrocortisone replacement. It was concluded that the hyperglycemia of shock probably results from epinephrine release leading to glycogenolysis with resultant hyperglycemia as well as the direct suppression of insulin secretion. It was concluded that the adrenal medullary secretions inhibit glucose assimilation as well in shock. The high incidence of pulmonary complications following shock remains unchanged. The authors have developed a method to evaluate capillary damage which is likely to be one of the earliest pathologic events. This then leads to the development of interstitial edema, another area which has received considerable attention, fall in compliance and functional residual capacity. These latter two phenomena have been examined with regard to their influence on respiratory gas exchange and therapeutic manouvers designed to optomize lung function. Author Modified Abstract
- Medicine and Medical Research