Effect of Marrow Storage on Graft-Versus-Host Disease in the Irradiated Rhesus Monkey.
Final rept. 1965-1966,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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One of the problems that has limited the effectiveness of bone marrow engraftment by transplantation of allogeneic marrow for the treatment of radiation injury has been the graft-versus-host response, which has been designated as the secondary disease in rodents and primates. Among possibilities to control this response has been the storage of the graft under varying conditions of temperature and for different periods of time prior to reinfusion. Preliminary observations indicated a tendency for enhanced survival with 24-hour storage of the monkey marrow at 2-4C. In order to test the hypothesis that storage under these specified conditions would enhance survival, the following experiment was carried out. Thirty rhesus monkeys were used in two comparative groups with allogeneic transplants either immediately after irradiation or after 24 hours of marrow storage following the irradiation exposure. Analysis of the data indicates that there was no significant difference between the mean survival times of the two groups. Author
- Medicine and Medical Research