Oxygen and Trauma: Studies on Pulmonary Oxygen Poisoning and the Role of Oxygen in Repair Processes.
Final technical rept.,
TURKU UNIV (FINLAND) DEPT OF MEDICAL CHEMISTRY
Pagination or Media Count:
Development of pulmonary poisoning in rats produced accumulation of cells, alveolar phospholipids and components of pulmonary interstitium in the endobronchial extracts. Recovery from the exudative phase occurred by fibrosis formation. Chronic intermittent exposure to oxygen also produced pulmonary fibrosis. Tissue hypoxia developed in rabbits at final phases of O2 poisoning because of the reduced uptake in lungs. A new method of determining tissue gases using implanted Silastic tube is described. The tube is filled with saline, which equilibrates to the average pO2 and pCO2 of the surrounding tissue. The fluid is then collected in a glass capillary tube for the assay of tissue gases. The method was applied to measurements in human subcutaneous tissue, healing rabbit tibias, staphylococcal osteomyelitis, peritoneal cavity and colonic wall of the rabbit. Wound nutrition was investigated in patients operated for mammary cancer. The main reason for decreased O2 supply in radical mastectomy wounds was excessive accumulation of wound fluid. Wound metabolism was studied in rats exposed to systemic hyperoxia, hypoxia or air. An over-all shift towards aerobic glycolysis occurred at elevated O2 supply. Wound ischemia retarded healing but hyperbaric oxygenation counteracted the delay due to disturbed blood supply. Author
- Medicine and Medical Research