Accession Number:

AD0757156

Title:

Kinetic Evidence for a Unique High Affinity Uptake System for Choline in Rat Brain Synaptosomes.

Descriptive Note:

Technical rept. Aug 71-Jul 72,

Corporate Author:

EDGEWOOD ARSENAL MD

Personal Author(s):

• Yamamura,Henry I.
• Gardner,Tommy L.
• Fedele,Louis A.
• Snyder,Solomon H.

Report Date:

1973-01-01

Pagination or Media Count:

15.0

Abstract:

Synaptosomes from rat brain accumulate choline by two kinetically distinct processes, a high-affinity uptake system Km .000001 M and a low-affinitysystem Km .00009 M. The high-affinity uptake has an absolute requirement for sodium and is associated with considerable formation of acetylcholine. By contrast the low-affinity uptake system has much less dependence on sodium and does not appear to be associated with a marked degree of acetylcholine formation. The high-affinity choline uptake appears to represent choline accumulation selectively by cholinergic neurons. Author

Descriptors:

• *CHOLINES
• *BRAIN
• BIOLOGICAL ABSORPTION
• ACETYLCHOLINE
• NERVE CELLS
• DYNAMICS

Subject Categories:

• Biochemistry
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE