Kinetic Evidence for a Unique High Affinity Uptake System for Choline in Rat Brain Synaptosomes.
Technical rept. Aug 71-Jul 72,
EDGEWOOD ARSENAL MD
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Synaptosomes from rat brain accumulate choline by two kinetically distinct processes, a high-affinity uptake system Km .000001 M and a low-affinitysystem Km .00009 M. The high-affinity uptake has an absolute requirement for sodium and is associated with considerable formation of acetylcholine. By contrast the low-affinity uptake system has much less dependence on sodium and does not appear to be associated with a marked degree of acetylcholine formation. The high-affinity choline uptake appears to represent choline accumulation selectively by cholinergic neurons. Author
- Anatomy and Physiology