Accession Number:
AD0757156
Title:
Kinetic Evidence for a Unique High Affinity Uptake System for Choline in Rat Brain Synaptosomes.
Descriptive Note:
Technical rept. Aug 71-Jul 72,
Corporate Author:
EDGEWOOD ARSENAL MD
Personal Author(s):
Report Date:
1973-01-01
Pagination or Media Count:
15.0
Abstract:
Synaptosomes from rat brain accumulate choline by two kinetically distinct processes, a high-affinity uptake system Km .000001 M and a low-affinitysystem Km .00009 M. The high-affinity uptake has an absolute requirement for sodium and is associated with considerable formation of acetylcholine. By contrast the low-affinity uptake system has much less dependence on sodium and does not appear to be associated with a marked degree of acetylcholine formation. The high-affinity choline uptake appears to represent choline accumulation selectively by cholinergic neurons. Author
Descriptors:
Subject Categories:
- Biochemistry
- Anatomy and Physiology