The Relative Effectiveness of Fission Neutrons for Gastrointestinal Damage in Mice: Lethality and Jejunal Crypt Response.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Mice were unilaterally irradiated in either a high neutron or a high gamma ray field. Median doses for gastrointestinal lethality LD506 were 350 rads and 882 rads for the neutron and gamma ray fields, respectively, following single pulsed exposures. Thus, the relative effectiveness of the neutron field at the LD506 dose level was 2.5. The percentage of jejunal crypts destroyed at various neutron and gamma ray doses was also determined. The relative effectiveness of the neutron field associated with jejunal crypt destruction ranged from 3.1 at 10 percent crypt destruction to 2.1 at 90 percent. A direct relation between destruction of jejunal crypts and animal lethality was demonstrated. Author