Evaluation of the Radioprotective Action of Chemical Agents
Final rept. for 1 Apr 1965-31 Dec 1972
CHICAGO UNIV IL
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The objective of this program was to screen compounds for radioprotective activity and to obtain information on those compounds found to have consistent activity. DRF studies were performed on 28 compounds that consistently protected at least 33 of the mice exposed to an otherwise lethal dose of X-irradiation. The compounds were tested in combination with mercaptoethylamine MEA, p-aminopropiophenone PAPP and both protective agents. Using cholinesterase and spleen weight changes as indices of injury, an effort was made to categorize the compounds as being protective primarily against intestinal or hematopoietic injury. To obtain information on the metabolic aspects of the WRAIR compounds an esterase inhibitor and a hepatic microsome enzyme inducer were given to mice. The toxicity and radioprotective activity of the compounds could be altered by alterations of the activity of metabolic enzymes. The toxicity of the WRAIR compounds alone and in combination with MEA and PAPP and with MEA alone was investigated. The WRAIR compounds are of relatively low toxicity to mice.