Accession Number:

AD0756585

Title:

Organotins for Antimalarial Screening

Descriptive Note:

Rept. no. 7 (Final), 15 Jun 1966-31 Oct 1968

Corporate Author:

STATE UNIV OF NEW YORK AT ALBANY RESEARCH FOUNDATION

Personal Author(s):

Report Date:

1973-01-05

Pagination or Media Count:

55.0

Abstract:

It was proposed to prepare for antimalarial screening organotins in four general categories 1 preparation of a variety of relatively simple organotins for general screening 2 introduction of organotin groups into quinine its derivatives 3 introduction of organotin groups into 4- aminoquinoline 4 introduction of organotin groups into sulfones which had shown some antimalarial activity. It was possible to carry on research on three of these categories. However, successful synthetic results were obtained only in the first of these. A total of forty three compounds was submitted for testing, and test results were returned on thirty six of these. These included unsaturated fulfones alkylallyltins alkylallenyltins alkylpyridines bicycloheptyltins and bis-salicylidenediaminoethane-alkyltin halide complexes. Some showed activity in mice, but were inactive or toxic in chicks and vice versa. None were active in both, and many were toxic in one or both.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE