The Effects of Decaborane on Cerebral Electrical Activity and Locomotor Behavior in the Cat
Final rept. 1 Apr 1971-31 Mar 1972
CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE
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Central nervous system effects of decaborane administered intraperitoneally in cats were evaluated electrophysiologically and in runway performance tests. It was found that overt behavioral and physiological manifestations of toxicity from this compound appeared at doses of 1 mgkg and above. These included depression of activity, general emesis, and weight loss. Runway performance showed significant disruption at doses of 0.5 and 0.25 mgkg. Marked individual variation was observed in the effects of exposure on performance at these low doses. Decaborane was found to be similar to MMH and UDMH in the rapid onset of behavioral disturbance at low doses. However, differences were observed between these compounds in that no seizure manifestations were noted with decaborane and recovery from behavioral disruption required at least several days. In the latter regard, decaborane more closely resembled hydrazine in its behavioral effects.