Tyrosine Aminotransferase Induction in Rat Liver as a Response to Irradiation and/or Flash Burn Injuries.
LOVELACE FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ALBUQUERQUE N MEX
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Tyrosine aminotransferase TAT activity was measured in rat liver to determine the extent to which thermal andor irradiation injury resulted in induction of TAT synthesis and to determine the relationship between the severity of injury and the extent of TAT induction. Flash burns elicited increased TAT activity in the liver, and the extent of induction was related to the severity of burn injury. Thermal injuries to the skin alone resulted in a detectable increase in TAT activity in about 30 percent of the animals, while deeper burns resulted in a uniform induction in all animals. The highest TAT activity occurred in the livers of animals just prior to death from thermal injuries. Irradiation alone did not lead to a detectable increase in TAT activity but resulted in a superinduction effect in animals exposed to skin burns. The latter was considered to result from interference with repressor formation due to genetic damage, resulting in uncontrolled TAT synthesis. Author