Release of Histamine from Mast Cells by Vasoactive Peptides.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
Pagination or Media Count:
The effect of a variety of synthetic pepides on rat mast cells was investigated. Peptides with two or more basic groups were active histamine releasers, while eledoisin, angiotensin I and II, glucagon, and fibrinopeptide A had slight or no activity. The activity of bradykinin analogues increased with the chain length. Des-arginine derivatives of bradykinin did not release histamine. The most potent histamine liberators were substance P and polistes kinin the activity of the latter one approached that of 4880. Because histamine could be released by the kinin peptide without disruption of the mast cell membrane, these agents like 4880, probably stimulate exocytosis of mast cell granules. Author