Comparative Effects of Interstitial Pulmonary Edema Produced by Venous Hypertension or Hemodilution in Perfused Lungs.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
Pagination or Media Count:
Edema formation in isogravimetric perfused lungs produced by elevated pulmonary venous pressure is distinctly different from that produced by progressive hemodilution of the perfusate. With venous pressures elevated from 0 to 10 mm Hg, pulmonary capillary pressure increased and pulmonary venous oxygen tension and effective compliance decreased. Hemodilution of the perfusate resulted in decreased pulmonary capillary pressure, improved oxygenation, and decreased effective compliance. Microscopically, elevated venous pressure resulted in an early appearance of perivenular interstitial edema, while hemodilution produced alveolar wall edema without localization to any particular vascular segment. These findings suggest that hemodilution alone may not be adequate to explain progressive respiratory insufficiency after resuscitation from shock, unless elevated pulmonary venous pressure is coexistent or there is a decreased threshold to edema formation. Author
- Anatomy and Physiology
- Medicine and Medical Research