Prevention of Pulmonary Oxygen Toxicity: Conclusions.
SAINT VINCENT'S HOSPITAL AND MEDICAL CENTER OF NEW YORK N Y DEPT OF PATHOLOGY
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Two different methods were tested in order to diminish the effects of oxygen toxicity on experimental animals. First Rats received various antioxidants separately or in mixtures. Their efficacy in preventing or modifying the morbidity and mortality in an atmosphere of 100 oxygen was determined. The antioxidants, vitamin E, ascorbic acid, butylated hydroxyanisole BHA and butylated hydroxytoluene BHT decreased the mortality of choline deficient rats. Second The possibility of abolishing sensitivity to pure oxygen by gradual adaptation was explored. Animals exposed to pure oxygen died within 65 hours while rats adapted to 85 O2 for 5-7 days showed increased tolerance to pure oxygen. Adapted animals survived for 7 days with some deaths by 20 days. The O2 concentration during the adaption period and its duration was varied in this study in order to determine the mix at which at least 90 of the rats will survive indefinitely arbitrarily defined as 30 days. The extent of fibrosis and other chronic morphologic changes producted by varied forms of adaptation was also compared.