Accession Number:

AD0755162

Title:

Sequential Search of an Optimal Dosage for Cases of Linear Dosage - Toxicity Regression.

Descriptive Note:

Technical rept.,

Corporate Author:

CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF MATHEMATICS AND STATISTICS

Personal Author(s):

• Eichhorn,Benjamin H.

Report Date:

1972-12-01

Pagination or Media Count:

14.0

Abstract:

The problem of determining the optimal dosage is studied for the case of normal distribution of toxicity, with a linear dosage- toxicity relationship. Both the slope and the intercept of the regression line are unknown. A sequential search procedure is derived which is feasible and strongly consistent. A numerical illustration through simulation is given at the end. Author

Descriptors:

• (*TOXIC TOLERANCES
• *SEQUENTIAL ANALYSIS)
• (*DOSAGE
• *TOXICITY)
• PERMISSIBLE DOSAGE
• THRESHOLDS(PHYSIOLOGY)
• REGRESSION ANALYSIS
• STATISTICAL ANALYSIS
• MATHEMATICAL MODELS

Subject Categories:

• Toxicology
• Statistics and Probability

Distribution Statement:

APPROVED FOR PUBLIC RELEASE