Accession Number:

AD0755127

Title:

Dimethylheptyl-Delta 6a-10a-Tetrahydrocannabinol: Effects after Parenteral Administration to Man

Descriptive Note:

Technical rept. Jun 1964-Oct 1969

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Report Date:

1972-12-01

Pagination or Media Count:

29.0

Abstract:

The eight optical isomers of dimethylheptylpyran as the acetate ester were administered parenterally to normal subjects. The main effect was hypotension which was most prominent when the subjects stood. In the doses used, isomers 2 and 4 and their mixtures were the only ones possessing biological activity. Doses of 1 to 2 micro grkg produced a pronounced and prolonged orthostatic hypotension. A resting tachycardia occurred with isomer 4. Symptoms were those related to hypotension, plus dry mouth, thirst and hunger, sleepiness, and irritated eyes with conjunctivitis suggesting a mild marihuana syndrome.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE