Bone Strength and In-Flight Mechanical Stresses.
Annual rept. no. 1,
DAYTON UNIV OHIO RESEARCH INST
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Twelve rhesus monkeys, in four groups of three each, were implanted with resorbable calcium aluminate ceramic femur sections. Each group contained a ceramic of different chemical composition and crystallographic structure. Four other rhesus monkeys underwent surgery for the removal and immediate replacement of a segment of their femur and were used as controls. One animal in each group was sacrificed after 60, 120, and 180 days. Radiographic observations and biochemical serum and urine analysis was performed throughout the implant periods. Scanning electron microscopy, reflected light microscopy, microradiography, histology, and electron-microprobe analysis were performed on ceramic-bone samples after sacrifice. These observations are compared with the microstructural analysis of the four different types of ceramics prior to implanting. A detailed comparison of the four different ceramics relative to one another and to the control samples is also given. It was concluded that a The ceramics used possessed adequate mechanical strength for use as femur sections in rhesus monkeys for up to 180 days when used in combination with an intermedullary fixation device. 2 The chemical composition of the implant definitely affects the type of organic tissue that forms. Author
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