Accession Number:

AD0754588

Title:

Prognoses of Antimalarial Effectiveness from Studies of Relationships Between Molecular Constitution and Chemotherapeutic Response.

Descriptive Note:

Summary rept. no. 7, 1 Jul 65-30 Jun 71,

Corporate Author:

TENNESSEE UNIV MEDICAL UNITS MEMPHIS DEPT OF MOLECULAR AND QUANTUM BIOLOGY

Personal Author(s):

• Purcell,William P.

Report Date:

1971-06-01

Pagination or Media Count:

31.0

Abstract:

The purpose of this project was to augment the existing programs within malaria research by providing expertise in the area of quantatative structure activity relationships and the development of the chemical structuresub-structure searching computer programs. The methodology employed was essentially that of applying the laws of mathematics, physics, and chemistry to the problem of selecting molecules for synthesis and evaluation which would have relatively high probability for success as antimalarials. Many compounds were suggested and they are included in this report. As a biproduct of the main thrust of drug design, insight was gained regarding the mechanism of action of antimalarials and these results are summarized here and published in the scientific literature. Author

Descriptors:

• *PHARMACOLOGY
• *MOLECULAR ORBITALS
• ANTIMALARIALS
• MOLECULAR STRUCTURE
• CINCHONA ALKALOIDS
• RESISTANCE(BIOLOGY)
• CHEMOTHERAPEUTIC AGENTS
• PLASMODIUM
• PARASITIC DISEASES
• MATHEMATICAL MODELS

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE