Blood Affinity for Oxygen in Hemorrhagic and Endotoxic Shock.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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Hemoglobin affinity for oxygen and red cell 2,3-diphosphoglycerate 2,3-DPG were evaluated in relation to other parameters of oxygen transport in experimental hemorrhagic and endotoxic shock. Eight rhesus monkeys were studied before and at intervals for 4 hr after the development of shock induced by the administration of Escherichia coli endotoxin. Seven other animals were phlebotomized to produce hemodynamically comparable hemorrhagic shock. The two groups had similar reductions in blood pressure and cardiac output. Oxygen consumption was unchanged during the study. Hemoglobin concentration was reduced in both groups but to a greater degree in those in hemorrhagic shock. The most striking physiological difference in parameters measured was more severe metabolic acidosis in the endotoxin group. The animals in hemorrhagic shock had a uniform increase in P50 mean increase 2.9 mm Hg. The animals in endotoxin shock varied considerably with no significant change in P50. No consistent or statistically significant changes in 2,3-DPG were observed in either group. It is unlikely that 2,3-DPG-related changes in P50 play a major role in augmenting oxygen delivery early in experimental shock. Author
- Medicine and Medical Research