Accession Number:

AD0753934

Title:

Uptake of Fe59 and Cr51 by Dog Red Blood Cells of Different Age Groups.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

• DeVenuto,Frank
• Donofrio,James C.
• Zegna,Angelo I.
• Shields,Charles E.

Report Date:

1972-09-25

Pagination or Media Count:

17.0

Abstract:

Using the four-phase centrifugation system, five fractions of blood are obtained. The results of in vivo and in vitro uptake of Fe59 show that, initially, this isotope is associated with the erythrocyte fraction of low density young cells with longer time interval after Fe59 injection or increased storage time, the radioactivity shifts to the fractions of cells with higher gravity. Plasma does not retain any significant amount of radioiron either in the in vivo or in vitro experiment. In contrast to Fe59 uptake, the in vitro studies with Cr51 show that this isotope is retained by the fraction of erythrocytes of higher density. Author

Descriptors:

• *ERYTHROCYTES
• LIFE SPAN(BIOLOGY)
• AGING(PHYSIOLOGY)
• LABELED SUBSTANCES
• RADIOACTIVE ISOTOPES
• CELLS(BIOLOGY)
• BIOCHEMISTRY
• BIOPHYSICS
• DENSITY
• IN VIVO ANALYSIS
• IN VITRO ANALYSIS
• IRON
• CHROMIUM

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE