Anaphylactic Deaths: A Clinicopathologic Study of 43 Cases
ARMED FORCES INST OF PATHOLOGY WASHINGTON DC
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The present study has enumerated the clinical and pathologic features in 43 anaphylactic deaths. A diagnosis of anaphylaxis cannot be made on morphologic grounds alone, for the anatomic changes are nonspecific and may occur in a host of other conditions. Pertinent clinical aspects for example, acute respiratory distress or sudden ciruclatory collapse within a few minutes following administration of the allergenic drug or agent combined with pathologic findings such as pulmonary congestion or hemorrhage, acute pulmonary emphysema, or edema of the upper airways are features that characterize and substantiate anaphylactic reactions in man. The short interval between exposure and the systemic reaction to the offending agent appears as a critically important clinical feature in drug-induced anaphylactic reactions.
- Medicine and Medical Research