Regulation of Corticosteroid Synthesis and Secretion.
Final technical rept. 1 Oct 55-30 Sep 72,
CALIFORNIA UNIV LOS ANGELES CENTER FOR HEALTH SCIENCES
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The research has been directed toward two major problems a localization and control of neurohumoral pathways in the brain which regulate pituitary release of ACTH and b the physiological mechanisms and biochemical factors involved in the control of adrenal steroid production. Of particular interest was the finding that slow modulatory and rapid stress-induced elevations in plasma corticosteroid levels may activate separate central mechanisms, possibly as a result of variations in thresholds to the activating stimuli. In addition, a scheme for a proposed interrelationship of the factors involved in the regulations of adrenocortical steroidogenesis is presented. Author
- Anatomy and Physiology