Accession Number:

AD0753051

Title:

Regulation of Corticosteroid Synthesis and Secretion.

Descriptive Note:

Final technical rept. 1 Oct 55-30 Sep 72,

Corporate Author:

CALIFORNIA UNIV LOS ANGELES CENTER FOR HEALTH SCIENCES

Personal Author(s):

• Roberts,Sidney

Report Date:

1972-11-01

Pagination or Media Count:

11.0

Abstract:

The research has been directed toward two major problems a localization and control of neurohumoral pathways in the brain which regulate pituitary release of ACTH and b the physiological mechanisms and biochemical factors involved in the control of adrenal steroid production. Of particular interest was the finding that slow modulatory and rapid stress-induced elevations in plasma corticosteroid levels may activate separate central mechanisms, possibly as a result of variations in thresholds to the activating stimuli. In addition, a scheme for a proposed interrelationship of the factors involved in the regulations of adrenocortical steroidogenesis is presented. Author

Descriptors:

• (*CORTICOSTEROID AGENTS
• BIOSYNTHESIS)
• SECRETION
• BRAIN
• PHYSIOLOGY
• BIOCHEMISTRY
• ADRENAL GLANDS
• PITUITARY GLAND
• STRESS(PSYCHOLOGY)
• STEROIDS

Subject Categories:

• Biochemistry
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE