Low Frequencies, Motile Cells, Measurements and Models. Part I. The Effects of Low Frequency Electric Fields on Amoebae and Their Uses as Tools for Studying Cellular Structure.
Medical research progress rept. no. 6,
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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Several dramatic phenomena were investigated that are produced in amoeboid cells by low frequency, low strength electric fields and currents. The surface coat of the cell has been found to play a very important role in these phenomena. A powerful method, based on electrical engineering methods, has resulted for elucidating and measuring the internal structures, parameters, and processes of intact, living, moving cells without the use of internal mechanical probes. This method can be termed frequency analysis of an experimental transcellular transfer function. It has immediate applications in biomedical, biological, biophysical, and biochemical research, and possible longer range practical applications as a diagnostic tool in medicine. It is an appropriate tool for making rational evaluations of the effects of electric fields and currents on living organisms, and ascertaining their significance. It could serve as the basis for far more sophisticated investigations which would provide a dynamic picture of living cells as organized systems in a way that has not been previously possible. Author
- Anatomy and Physiology