Experimental Mutability of Venezuelan Equine Encephalitis Virus. Part I. Properties of Mutants Induced by Alkylating Compounds
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The induced mutability of the Venezuelan equine encephalomyelitis virus affecting many of its characters was studied. Alkylating compound formaldehyde, nitrosomethylurea and ethyleneimine were used as mutagens. It was established that nitrosomethylurea posessed the greatest mutagenic activity, the frequency of mutations induced being 42.5. There was no difference in this respect between formaldehyde and ethyleneimine both 33.0. In the spectrum of mutations affecting the pathogenicity formaldehyde surpasses two other mutagens. Besides it induced mutations characterized by the formation of small plaques. The changes of pathogenicity caused by mutations were associated with the changes of certain other genetic characters.