The Phenomenon of Hybrid Ribonucleoprotein Complexes ('Pseudoviruses') Formation
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK
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During reproduction of some RNA viruses or after exposure of the infectious RNA isolated from the virions with various cytoplasmatic fractions of the animal cells the formation of hibrid RNP-complexes pseudoviruses is recorded. These present characteristic biological and physico-chemical properties infectivity, resistance to antiviral sera, partial sensitivity to the action of ribonuclease, sedimentation constants ranging between 80S and 160S, buoyant density in the Cesium gradient from 1.30 to 1.43 gcc.