Experimental Mutability of Venezuelan Equine Encephalitis Virus. Part 2. Properties of Mutants Induced by Nitrous Acid
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The changes of characteristics of Venezuelan equine encephalomyelitis virus VEE induced by nitrous acid were studied. The treatment of VEE virus by this mutagen resulted in the initiation of mutations affecting the character of pathogenicity, but not mutations affecting only the size of negative plaques were observed. Mutants with lacking or reduced pathogenicity for animals were characterized by small negative plaques, by a low rate of virusemia and by thermolability. Besides these mutants posessed pronounced antigenic and immunogenic characteristics.