Accession Number:

AD0752177

Title:

Experimental Mutability of Venezuelan Equine Encephalitis Virus. Part 2. Properties of Mutants Induced by Nitrous Acid

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Report Date:

1972-01-01

Pagination or Media Count:

7.0

Abstract:

The changes of characteristics of Venezuelan equine encephalomyelitis virus VEE induced by nitrous acid were studied. The treatment of VEE virus by this mutagen resulted in the initiation of mutations affecting the character of pathogenicity, but not mutations affecting only the size of negative plaques were observed. Mutants with lacking or reduced pathogenicity for animals were characterized by small negative plaques, by a low rate of virusemia and by thermolability. Besides these mutants posessed pronounced antigenic and immunogenic characteristics.

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE