Relationship between Biological Properties of the Venezuelan Equine Encephalomyelitis Virus and Sizes of the Virions
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
In natural genotypes of the Venezuelan equine encephalomyelitis virus there is a correlation between the size of the virion and the size of the plaques. The thermostability of the virus, its pathogenicity for white mice, and its capacity for multiplication at 40C do not depend upon the size of the virus particles. Clones of the virus with relatively small and middle-sized virions are characterized by the capacity for autominterference and by sensitivity to the inhibiting effect of agar polysaccharides. In clones with large virions, these genetic characteristics may show an opposite phenotypic manifestation. These regularities do not hold true for temperature mutants which have lost pathogenicity for white mice and have lost the capacity for multiplication at 40C. The size of the virions undergoes changes in the course of mutations induced by 5-fluorouracil. The observed increase in the size of virions in mutants is accompanied by loss of the capacity of the virus to produce large plaques.