Radiobiology of Large Animals
STANFORD RESEARCH INST MENLO PARK CA
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A review has been completed of all experiments concerned with radiation-induced lethality in sheep and conducted by the Naval Radiological Defense Laboratory andor the Stanford Research Institute under the auspices of the Defense Civil Preparedness Agency. After consideration of a series of experiments involving sheep exposed at various continuous, intermittent, or combined irradiation schedules at dose rates of 4 Rhr or less, it appears that the major factor determining mortality in such experiments is the average dose per day over the entire exposure period, and not the specific dose rate during the irradiation itself. A mathematical model has been developed that describes the dynamics of injury and repair as a function of daily average dose rate.